Binding of Isaac already has a real art style with vectorial characters and textures...
I don't think many users would like PureBDcraft for this title.
I would be very happy to work on another game to port/adapt PureBDcraft on but I think the best games for PureBDcraft are the retro-ones with pixelated graphics.
The next (indie)game already planned (and started) for PureBDcraft is Eldritch. But I have many other things planned too.
So my priority goed to the projects where the most users asked for or would be interested in.
By the way if someone has started a proof of concept of texturepackfor any game, that would greatly help and make the project be added in the todolist list.